Kentacef may be available in the countries listed below.
Cefatrizine comp. with propylene glycole (a derivative of Cefatrizine) is reported as an ingredient of Kentacef in the following countries:
International Drug Name Search
Apo-Trifluoperazine may be available in the countries listed below.
Trifluoperazine is reported as an ingredient of Apo-Trifluoperazine in the following countries:
Trifluoperazine hydrochloride (a derivative of Trifluoperazine) is reported as an ingredient of Apo-Trifluoperazine in the following countries:
International Drug Name Search
Generic Name: metronidazole vaginal (MET roe NYE da zole)
Brand Names: MetroGel-Vaginal, Vandazole
Metronidazole is an antibiotic that fights bacteria in the body.
Metronidazole vaginal is used to treat vaginal infections caused by bacteria.
Metronidazole vaginal may also be used for other purposes not listed in this medication guide.
Do not use metronidazole vaginal if you have ever had an allergic reaction to it.
Before using metronidazole vaginal, tell your doctor if you have liver disease, a seizure disorder, problems with circulation (such as Raynaud's syndrome), or if you have taken disulfiram (Antabuse) within the past 14 days.
Avoid having sex until your vaginal infection has been completely treated and you have finished using the medication.
Avoid using other vaginal creams or douches at the same time as metronidazole vaginal unless your doctor approves.
Do not use metronidazole vaginal if you have ever had an allergic reaction to it.
Before using metronidazole vaginal, tell your doctor if you are allergic to any drugs, or if you have:
liver disease;
a seizure disorder; or
problems with circulation (such as Raynaud's syndrome).
If you have any of these conditions, you may need a dose adjustment or special tests to safely use metronidazole vaginal.
Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
Insert the cream into your vagina using the applicator as directed.
Your medication may come with disposable applicators. Use each applicator for only 1 day and then throw it away. If you use the medication twice daily, wash and rinse the applicator after your morning dose and use it again for your evening dose. Then throw it away and use a new applicator the next day.
Use metronidazole vaginal for the entire length of time prescribed by your doctor, even during your menstrual period. Your symptoms may get better before the infection is completely treated.
You may need to use a sanitary napkin during treatment, but do not use a tampon.
Metronidazole vaginal can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using this medication.
Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
An overdose of metronidazole applied in the vagina is not expected to produce life-threatening symptoms.
Avoid wearing tight-fitting, synthetic clothing such as nylon underwear or panty hose that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until your infection is healed.
Avoid having sex until your vaginal infection has been completely treated and you have finished using the medication.
Avoid using other vaginal creams or douches at the same time as metronidazole vaginal unless your doctor approves.
Rare but serious side effects may include:
seizure (convulsions); or
numbness, burning, pain, or tingly feeling in your hands or feet.
Less serious side effects may include:
mild burning or stinging when the medication is applied;
pelvic pain or cramps;
loss of appetite, constipation, upset stomach, vomiting;
dizziness, sleep problems (insomnia);
runny nose;
urinating more than usual;
acne, increased sweating; or
breast discharge or enlargement.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor if you have taken disulfiram (Antabuse) within the past 14 days. Also tell your doctor if you are using:
cimetidine (Tagamet);
lithium (Eskalith, Lithobid, Lithonate); or
a blood thinner such as warfarin (Coumadin).
There may be other drugs that can interact with metronidazole vaginal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
See also: Vandazole side effects (in more detail)
Blefamide may be available in the countries listed below.
Sulfacetamide sodium salt (a derivative of Sulfacetamide) is reported as an ingredient of Blefamide in the following countries:
International Drug Name Search
Fematrix
40
transdermal patch
Please read this leaflet before you take your medicine, and keep it safe because you may want to read it again. If you have any questions or are not sure about anything, ask your doctor or a pharmacist.
Fematrix belongs to a group of medicines known as Hormone Replacement Therapy or HRT.
Fematrix 40 is a self-adhesive transdermal patch containing 1.25 mg of estradiol. Each patch delivers approximately 40 micrograms of estradiol in 24 hours. The patch is rectangular in shape with rounded corners and comes in a sachet. Each box contains 8 sachets, each containing one patch.
The estradiol in Fematrix 40 is made from plant materials. The patch also contains: diethyltoluamide, acrylic adhesive (Dow Corning MG-0560) and acrylic thickener (Acrysol 33).
The marketing authorisation holder is
Fematrix 40 patches are manufactured by
Fematrix is an estrogen only HRT for peri and postmenopausal women, used to treat the symptoms of the menopause (change of life). These symptoms vary from woman to woman, and can include hot flushes, night sweats, sleeping difficulties, dryness of the vagina and urinary problems.
Fematrix is suitable for peri and postmenopausal women who may or may not still be having their periods and women switching from standard (cyclic or sequential) HRT on the advice of their doctor.
Fematrix 40 is not a contraceptive. If you need contraception you should use a non-hormonal method.
Fematrix contains estradiol. This hormone replaces the estradiol you produce in your ovaries from puberty until the menopause. Your body's natural estrogen is also called estradiol.
Estradiol replaces your body's natural estrogen, controlling your menopausal symptoms. Women who still have a womb should normally take some form of progesterone (a progestagen), because estrogen alone can cause problems due to a build up of the womb lining. When needed, a progestagen such as dydrogesterone 10 mg should normally be added to Fematrix for 12 - 14 days each month. Taking dydrogesterone for part of each monthly cycle (with Fematrix) helps prevent a build up of the womb lining by inducing a regular monthly bleed (see ‘endometrial cancer’).
Before you take your medicine, you should make sure that it is safe for you to do so. If you answer yes to any of the following questions, do not take Fematrix:
If any of the following apply to you, you should check with your doctor before you start taking Fematrix:
Before you start taking HRT, your doctor should ask about your own and your family’s medical history. Your doctor may decide to examine your breasts and/or your abdomen, and may do an internal examination - but only if these examinations are necessary for you, or if you have any special concerns.
Once you’ve started on HRT, you should see your doctor for regular check-ups (at least once a year). At these check-ups, your doctor may discuss with you the benefits and risks of continuing to take HRT.
Be sure to:
If you have (or had in the past, or are at risk of getting) any of the following conditions, your doctor may want to see you more often for check-ups:
As well as benefits, HRT has some risks which you need to consider when you’re deciding whether to take it, or whether to carry on taking it.
Effects on your heart or circulation
Heart disease
HRT is not recommended for women who have heart disease, or have had heart disease recently. If you have had heart disease, talk to your doctor to see if you should take HRT.
HRT will not help to prevent heart disease.
Studies with one type of HRT (containing conjugated estrogen plus the progestagen MPA), have shown that women may be slightly more likely to get heart disease during the first year of taking the medication. For other types of HRT, the risk is likely to be similar, although this is not yet certain.
If you get:
Stroke
Recent research suggests that HRT slightly increases the risk of having a stroke. Other things that can increase the risk of stroke include:
If you are worried about any of these things,
or if you have had a stroke in the past, talk to your doctor to see if you should take HRT.
Compare
Looking at women in their 50s who are not taking HRT - on average, over a 5-year period, 3 in 1000 would be expected to have a stroke.
For women in their 50s who are taking HRT, the figure would be 4 in 1000.
Looking at women in their 60s who are not taking HRT - on average, over a 5-year period, 11 in 1000 would be expected to have a stroke.
For women in their 60s who are taking HRT, the figure would be 15 in 1000.
If you get:
Blood clots
HRT may increase the risk of blood clots in the veins (also called deep vein thrombosis, or DVT), especially during the first year of taking it.
These blood clots are not always serious, but if one travels to the lungs, it can cause chest pain, breathlessness, collapse or even death. This condition is called pulmonary embolism, or PE.
DVT and PE are examples of a condition called venous thromboembolism, or VTE.
You are more likely to get a blood clot:
If any of these things apply to you,
talk to your doctor to see if you should take HRT.
Compare
Looking at women in their 50s who are not taking HRT — on average, over a 5-year period, 3 in 1000 would be expected to get a blood clot.
For women in their 50s who are taking HRT, the figure would be 7 in 1000.
Looking at women in their 60s who are not taking HRT — on average, over a 5-year period, 8 in 1000 would be expected to get a blood clot.
For women in their 60s who are taking HRT, the figure would be 17 in 1000.
If you get:
If you’re going to have surgery,
make sure your doctor knows about it. You may need to stop taking HRT about 4 to 6 weeks before the operation, to reduce the risk of a blood clot. Your doctor will tell you when you can start taking HRT again.
Effects on your risk of developing cancer
Breast cancer
Women who have breast cancer, or have had breast cancer in the past, should not take HRT. Taking HRT slightly increases the risk of breast cancer; so does having a later menopause. The risk for a post-menopausal woman taking estrogen-only HRT for 5 years is about the same as for a woman of the same age who’s still having periods over that time and not taking HRT. The risk for a woman who is taking estrogen plus progestagen HRT is higher than for estrogen-only HRT (but estrogen plus progestagen HRT is beneficial for the endometrium, see ‘Endometrial cancer’ below).
For all kinds of HRT, the extra risk of breast cancer goes up the longer you take it, but returns to normal within about 5 years after stopping.
Your risk of breast cancer is also higher:
Compare
Looking at women aged 50 who are not taking HRT — on average, 32 in 1000 will be diagnosed with breast cancer by the time they reach the age of 65.
For women who start taking estrogen-only HRT at age 50 and take it for 5 years, the figure will be 33 and 34 in 1000 (ie an extra 1-2 cases).
If they take estrogen-only HRT for 10 years, the figure will be 37 in 1000 (an extra 5 cases).
For women who start taking estrogen plus progestagen HRT at age 50 and take it for 5 years, the figure will be 38 in 1000 (ie an extra 6 cases).
If they take estrogen plus progestagen HRT for 10 years, the figure will be 51 in 1000 (ie an extra 19 cases).
If you notice
any changes in your breast, such as:
Endometrial cancer (cancer of the lining of the womb)
Taking estrogen-only HRT for a long time can increase the risk of cancer of the lining of the womb (the endometrium). Taking a progestagen as well as the estrogen helps to lower the extra risk.
If you still have your womb, your doctor may prescribe a progestagen as well as estrogen. If so, these may be prescribed separately, or as a combined HRT product.
If you have had your womb removed (a hysterectomy), your doctor will discuss with you whether you can safely take estrogen without a progestagen.
If you’ve had your womb removed because of endometriosis, any endometrium left in your body may be at risk. So your doctor may prescribe HRT that includes a progestagen as well as an estrogen.
Your product, Fematrix is an estrogen-only product
Compare
Looking at women who still have a uterus and who are not taking HRT – on average 5 in 1000 will be diagnosed with endometrial cancer between the ages of 50 and 65.
For women who take estrogen-only HRT the number will be 2 to 12 times higher, depending on the dose and how long you take it.
The addition of a progestagen to estrogen-only HRT substantially reduces the risk of endometrial cancer.
If you get
breakthrough bleeding or spotting, it’s usually nothing to worry about, especially during the first few months of taking HRT.
But if the bleeding or spotting:
Ovarian cancer
Ovarian cancer (cancer of the ovaries) is very rare, but it is serious. It can be difficult to diagnose, because there are often no obvious signs of the disease.
Some studies have indicated that taking estrogen-only HRT for more than 5 years may increase the risk of ovarian cancer. It is not yet known whether other kinds of HRT increase the risk in the same way.
If you are taking anticonvulsants (eg. phenobarbital, phenytoin, carbamazepine), anti-infectives (e.g. rifampicin, rifabutin, nevirapine, efavirenz), ritonavir, nelfinavir or herbal preparations containing St John’s wort (Hypericum perforatum), talk to your doctor or a pharmacist. These other medicines may stop Fematrix working properly.
Generally your doctor will start you on Fematrix 40. Your doctor will aim to give you the lowest dose for the shortest time to treat your symptoms. The dose can then be increased, by your doctor, if necessary. One Fematrix patch should be applied twice weekly on a continuous basis. Each patch should be removed after 3 to 4 days and replaced with a new patch applied to a slightly different site. Patches should be applied to clean, dry and intact areas of skin below the waist on the lower back or buttocks. Fematrix should not be applied on or near the breasts.
In women with a uterus, a progestagen such as dydrogesterone 10 mg should normally be added to Fematrix for 12-14 days each month.
If you are having regular periods you should apply the first patch within five days of the start of bleeding. If you are not having regular periods and are not taking any other HRT preparations, or you are switching from a combined continuous HRT product, you can apply the patch on any convenient day.
If you are currently using a 'cyclic’ or ‘sequential' HRT preparation (which involves taking an estrogen tablet or patch for part of the month, followed by both estrogen and progestagen tablet or patch for up to 14 days) you should apply the first Fematrix patch the day after you finish the pack i.e. at the end of the progestagen phase.
If you forget to change your patch at the right time you should change it as soon as possible. But remember to follow your normal schedule for sticking on the next one. If you normally change your patch on a Monday and Thursday and you forget to change your Monday patch until Tuesday or Wednesday, then you must still change your next patch on Thursday. If a patch is missed or applied late, it is more likely that you will have irregular bleeds.
If your patch comes off before the day when you regularly change it and you cannot stick it back on, put a new patch on. You should then change this patch on your normal change day and carry on as usual.
You should stick the patch on dry, unbroken areas of your skin below the waistline such as your lower back or buttocks. Do not put the patch on or near the breasts.
When you have chosen the area where you want to put the patch, make sure the area is not red or irritated. Before you apply the patch, wash and dry the area where you are going to put it. Do not put any powder, oil or cream on your skin before you stick the patch on as this might prevent it from sticking properly.
Take one sachet out of the box and carefully tear it open. Take out the patch, take off the smaller piece of shiny backing covering the sticky side (see Figure 1) and put the patch on the area of skin you have chosen.
Gently peel off the rest of the backing and flatten the surface of the patch with your other hand as you pull (Figure 2). This should give a smooth and wrinkle-free surface.
Pressing it for a few seconds will make it stick firmly (Figure 3). As long as you have stuck the patch on correctly, you can bathe or shower with little risk of it coming off.
When the time comes to change the patch, take off the old one. Place your new patch on a fresh area of skin.
After use, fold the Fematrix patch in two with the adhesive surface to the inside and dispose with the normal household waste. Do not flush the patch down the toilet.
It is almost impossible to get an overdose of estradiol from Fematrix 40, but if you think you have, take off the patch(es) and tell a doctor.
Some women may have side effects when taking Fematrix, but they usually disappear after the first few months. In the list of possible side effects given below, we give an indication of how likely it is that you will get these side effects: ‘common’ means less than one in ten patients may experience this side effect; ‘uncommon’ means less than one in a hundred; ‘rarely’ means less than one in a thousand; and ‘very rarely’ means less than one in ten thousand patients.
Some patients may experience a mild and brief local rash at the site of application with or without itching; this usually disappears rapidly on removal of the patch.
Tumours related to estrogens (both benign and malignant) have been associated with HRT (see ‘Effect on your risk of developing cancer’ above).
Dementia: HRT will not prevent memory loss. In one study of women who started using combined HRT after the age of 65, a small increase in the risk of dementia was observed.
Usually, side effects are not common and do not usually last long. If any of these side effects do last for a long time or you notice any other side effects and you are worried about them, please contact your doctor or a pharmacist for advice.
You should stop taking Fematrix 40 and contact your doctor if:
Do not store above 25°C. Store in the original package. Do not use the patches after the expiry date shown on the pack. Store all medicines where children cannot see or reach them.
Take any unused patches back to a pharmacy (chemist).
This leaflet was revised in January 2006.
Remember
This medicine is for you. Please do not offer it to your family and friends, even if they have the same symptoms as you.
registered trade mark
Relieving symptoms of sinus congestion, runny nose, sneezing, itchy nose or throat, itchy or watery eyes, and cough due to colds, upper respiratory tract infections, or allergies. It may also be used for other conditions as determined by your doctor.
Phenylephrine/Pyrilamine/Dihydrocodeine Liquid is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Phenylephrine/Pyrilamine/Dihydrocodeine Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Phenylephrine/Pyrilamine/Dihydrocodeine Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenylephrine/Pyrilamine/Dihydrocodeine Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Phenylephrine/Pyrilamine/Dihydrocodeine Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Phenylephrine/Pyrilamine/Dihydrocodeine Liquid.
When used for long periods of time or at high doses, Phenylephrine/Pyrilamine/Dihydrocodeine Liquid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Phenylephrine/Pyrilamine/Dihydrocodeine Liquid stops working well. Do not take more than prescribed.
Some people who use Phenylephrine/Pyrilamine/Dihydrocodeine Liquid for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.
If you suddenly stop taking Phenylephrine/Pyrilamine/Dihydrocodeine Liquid, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; lightheadedness; loss of appetite; nausea; nervousness or anxiety; sweating; trouble sleeping; upset stomach or mild stomach pain; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes (eg, depression); persistent trouble sleeping; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; severe or persistent stomach pain; slow or shallow breathing; tremor; trouble urinating or inability to urinate; uncontrolled muscle movements; unusual bruising or bleeding; unusual weakness or tiredness; vision changes or blurred vision.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; cold and clammy skin; coma; confusion; hallucinations; limp muscles; seizures; severe dizziness, drowsiness, lightheadedness, or headache; slow or shallow breathing; small pupils; unusually fast, slow, or irregular heartbeat; vomiting.
Store Phenylephrine/Pyrilamine/Dihydrocodeine Liquid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phenylephrine/Pyrilamine/Dihydrocodeine Liquid out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Phenylephrine/Pyrilamine/Dihydrocodeine Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Venlafaxin AbZ may be available in the countries listed below.
Venlafaxine hydrochloride (a derivative of Venlafaxine) is reported as an ingredient of Venlafaxin AbZ in the following countries:
International Drug Name Search
